Hi! Welcome to the forum!
The beauty is that the API can be used with anything. Some people use ruby, some people use R, some guy made a fortran lib 
I’m personally a fan of node, but you sometimes do need to use python for some stuff. If you’re comfortable with it, it’s a very versatile option.
Regarding front ends, I’m starting to wonder if front end libraries are starting to lose their purpose - it’s so easy to whip something up from scratch with gpt-4/copilot with a little bit of practice.
And docker to tie it all together. Wrap everything into an image and you can run it anywhere.
But imo the choice of stack is person/team/project dependent.
What are you trying to build?